Howtoforge posted a tutorial about installing Nginx with PHP5 (and PHP-FPM) and MySQL support on Ubuntu 10.10

Nginx (pronounced "engine x") is a free, open-source, high-performance HTTP server. Nginx is known for its stability, rich feature set, simple configuration, and low resource consumption. This tutorial shows how you can install Nginx on an Ubuntu 10.10 server with PHP5 support (through PHP-FPM) and MySQL support.

  Installing Nginx With PHP5 (And PHP-FPM) And MySQL Support On Ubuntu 10.10