GloriousEggroll has released a new version of their Proton fork based on Wine Staging 6.0.

Game Fixes:

• Persona 4 Golden now playable but with issue -- in-game audio is broken. Cutscenes and cutscene audio are working.
• Fixed issue that prevented Death Stranding from running in 5.21
• Fixed issue with video playback in DmC 5 (again)
• Fixed issue preventing controllers from being detected in some games on certain distros
• Controller Hot Plugging now working
• Controller patches completely rebased from 5.13
• Mangohud now working
• Vulkan device select layer now working
• Wine updated to Wine-Staging 6.0
• gstreamer libraries updated to 1.18.3
• vkd3d updated to 2.1-037efbd to contain Dirt 5 fix
• dxil-spirv submodule in vkd3d updated to contain latest Horizon Zero Dawn fixes.
• DXVK updated, contains F1 game fixes
• DXVK pending pull requests 1582,1673,1759,1805 added:

doitsujin/dxvk#1582
doitsujin/dxvk#1673
doitsujin/dxvk#1759
doitsujin/dxvk#1805

• Should contain most of the fixes from Proton-5.13 from Valve, if something is missing let me know in discord.

Proton Fixes:

• added klite verb with ini for custom silent install for Persona 4 Golden
• updated Persona 4 Golden protonfixes script

Known Issues:

-The build uses proton's new runtime, which runs within a container, therefore all of the current Proton 5.13 issues also apply here.

ValveSoftware#4289

-Red Dead Redemption 2 still does not work. Unfortunately the syscall patches in current proton do not work with upstream wine.
-Fullscreen hack is still currently disabled.

Known mfplat+quartz issues:

-Catherine Classic is not working
-Black Ops III is not working
-Injustice 2 cutscenes broken currently
-Darksiders Warmastered Edition intro+cutscenes broken currently

Download Proton 6.0-GE-1 from GitHub
Installation Instructions