GloriousEggroll has released a new custom build of their Proton fork based on the latest Proton release.

This is my build of Proton with the most recent release of vanilla wine, has ffmpeg enabled for faudio by default, and all of Proton's patches ported over to be applied to wine, as well as wine-staging and vkd3d.

All patches:

-Warframe screenshot F6 patch -FFXIV Launcher patch -Mech Warrior online patch
-Assetto Corsa HUD patch -Vulkan child window patch
-sword art online gnutls patch
-d9vk integration
-vkd3d integration
-protonfixes integration
-FAudio with FFMpeg enabled (fixes audio/voices in multiple games)
-All of Valve's wine proton patches. Yes. All of them.
-wine staging patches
-various wine hot fixes for wine functionality that fix regressions per version

Change log:

-added fullscreen hack rebase from proton 5
-added updated steamclient rebase from proton 5 so that jc3 and batman AK denuvo problems work
-added updated monster hunter world patch that limits the changes to monster hunter world
-added proton patch that sets prefixes to win10 by default
-added dsound surround sound patches from proton 5
-proton dxvk wine integration patches added so that vkd3d works ootb without PROTON_USE_WINED3D
-reenabled proton's gamepad changes in favor over staging's (for now. let me know in discord if issues occur)
-updated to include proton's gstreamer and glib integration work
-added plasma systray patch
-fixed proton compatibility for staging patchset winex11.drv-mouse-coorrds
-disabled winex11-_NET_ACTIVE_WINDOW temporarily (not working correctly)
-disabled winex11-WM_WINDOWPOSCHANGING temporarily (depends on winex11-_NET_ACTIVE_WINDOW)
-updated dxvk to 1.5.4 official
-updated FAudio
-updated vkd3d

Known issues:
-Just Cause 3 not able to save

Download Proton 5.1-GE-1 from GitHub