Thomas Crider has announced a hotfix release for Proton-6.21-GE. This is a custom build of Proton with the most recent releases of vanilla WINE. It has FFmpeg enabled for FAudio by default, and all of Proton's patches ported over to be applied to WINE, as well as Wine-staging and VKD3D.
Proton-6.21-GE-1
This is a hotfix to apply the following important revert from Valve:
Additionally, the release files for Proton-6.21-GE-1 have been removed to aide in further preventing people from accidentally launching Destiny 2 and getting themselves banned, per the above hotfix.
Download Proton 6.21-GE-2 from GitHub
Installation Instructions