Howtoforge posted a guide about setting up CS-Cart with Nginx on Debian/Ubuntu

This tutorial shows how you can install and run CS-Cart on a Debian Wheezy or Ubuntu 13.04 system that has nginx installed instead of Apache (LEMP = Linux + nginx (pronounced "engine x") + MySQL + PHP). nginx is a HTTP server that uses much less resources than Apache and delivers pages a lot of faster, especially static files.

  Running CS-Cart On Nginx (LEMP) On Debian Wheezy/Ubuntu 13.04