Howtoforge posted a tutorial about running Drupal 7.7 on Nginx (LEMP) on Debian Squeeze/Ubuntu 11.04

This tutorial shows how you can install and run a Drupal 7.7 web site on Debian Squeeze or Ubuntu 11.04 with nginx installed instead of Apache (LEMP = Linux + nginx (pronounced "engine x") + MySQL + PHP). In addition to that I will also show you how you can use the Drupal Boost plugin with nginx. nginx is a HTTP server that uses much less resources than Apache and delivers pages a lot of faster, especially static files.

  Running Drupal 7.7 On Nginx (LEMP) On Debian Squeeze/Ubuntu 11.04