Howtoforge posted a tutorial about installing Shopware 4.0 on Nginx/Ubuntu

This tutorial shows how you can install and run the new Shopware version 4.0.x on an Ubuntu 12.04 system that has nginx installed instead of Apache (LEMP = Linux + nginx (pronounced "engine x") + MySQL + PHP). Shopware is a feature-rich ecommerce platform; I will use the Community Edition here which is free. nginx is a HTTP server that uses much less resources than Apache and delivers pages a lot of faster, especially static files.

  Running New Shopware Version 4.0.x On Nginx (LEMP) On Ubuntu 12.04