Howtoforge published a tutorial about running ownCloud3 on Nginx on Debian 6/Ubuntu 11.10 system

This tutorial shows how you can install and run ownCloud3 on a Debian Squeeze or Ubuntu 11.10 system that has nginx installed instead of Apache (LEMP = Linux + nginx (pronounced "engine x") + MySQL + PHP). ownCloud enables universal access to files through the widely implemented WebDAV standard, providing a platform to easily view and sync contacts, calendars and bookmarks across devices while supporting sharing, viewing and editing via the web interface. It offers the ease-of-use of Dropbox and box.net without vendor lock in. ownCloud users can run its file sync and share services on their own hardware. nginx is a HTTP server that uses much less resources than Apache and delivers pages a lot of faster, especially static files.

  Running ownCloud3 On Nginx (LEMP) On Debian Squeeze/Ubuntu 11.10