Howtoforge posted a guide about setting up Simple Groupware on Nginx on Debian Squeeze/Ubuntu 11.10

This tutorial shows how you can install and run Simple Groupware on a Debian Squeeze or Ubuntu 11.10 system that has nginx installed instead of Apache (LEMP = Linux + nginx (pronounced "engine x") + MySQL + PHP). Simple Groupware is an open source enterprise groupware that offers email, calendaring, contacts, tasks, document management, project management, synchronization with Outlook and cell phones, full-text search, extensions and many more. nginx is a HTTP server that uses much less resources than Apache and delivers pages a lot of faster, especially static files.

  Running Simple Groupware On Nginx (LEMP) On Debian Squeeze/Ubuntu 11.10