Howtoforge posted a tutorial about running WordPress on Nginx (LEMP) on Debian Squeeze/Ubuntu 11.04

This tutorial shows how you can install and run a WordPress blog on a Debian Squeeze or Ubuntu 11.04 system that has nginx installed instead of Apache (LEMP = Linux + nginx (pronounced "engine x") + MySQL + PHP). In addition to that I will also show you how you can use the WordPress plugins WP Super Cache and W3 Total Cache with nginx. nginx is a HTTP server that uses much less resources than Apache and delivers pages a lot of faster, especially static files.

  Running WordPress On Nginx (LEMP) on Debian Squeeze/Ubuntu 11.04