Howtoforge published a guide about setting up Fedora 10 as Linux desktop

This tutorial shows how you can set up a Fedora 10 desktop (GNOME) that is a full-fledged replacement for a Windows desktop, i.e. that has all the software that people need to do the things they do on their Windows desktops. The advantages are clear: you get a secure system without DRM restrictions that works even on old hardware, and the best thing is: all software comes free of charge.

The Perfect Desktop - Fedora 10 (GNOME)