Howtoforge posted a guide about setting up Linux Mint 13 as desktop replacement

This tutorial shows how you can set up a Linux Mint 13 (Maya) desktop that is a full-fledged replacement for a Windows desktop, i.e. that has all the software that people need to do the things they do on their Windows desktops. The advantages are clear: you get a secure system without DRM restrictions that works even on old hardware, and the best thing is: all software comes free of charge.

  The Perfect Desktop - Linux Mint 13 (Maya)