Howtoforge posted a tutorial about setting up Debian Squeeze with ISPConfig 2
This tutorial shows how to set up a Debian Squeeze (Debian 6.0) server that offers all services needed by ISPs and hosters: Apache web server (SSL-capable), Postfix mail server with SMTP-AUTH and TLS, BIND DNS server, Proftpd FTP server, MySQL server, Courier POP3/IMAP, Quota, Firewall, etc. In the end you should have a system that works reliably, and if you like you can install the free webhosting control panel ISPConfig 2 (i.e., ISPConfig runs on it out of the box).The Perfect Server - Debian Squeeze (Debian 6.0) ISPConfig 2