Howtoforge posted a guide about setting up Nginx with ISPConfig 3 on Ubuntu 12.10
This tutorial shows how to prepare an Ubuntu 12.10 (Quantal Quetzal) server (with nginx, BIND, Dovecot) for the installation of ISPConfig 3, and how to install ISPConfig 3. ISPConfig 3 is a webhosting control panel that allows you to configure the following services through a web browser: Apache or nginx web server, Postfix mail server, Courier or Dovecot IMAP/POP3 server, MySQL, BIND or MyDNS nameserver, PureFTPd, SpamAssassin, ClamAV, and many more. This setup covers nginx (instead of Apache), BIND (instead of MyDNS), and Dovecot (instead of Courier).The Perfect Server - Ubuntu 12.10 (nginx, BIND, Dovecot, ISPConfig 3)