The WineX 2.2.1 update is based on our stable 2.0 development branch, and fixes problems with some Linux distributions such as Debian Unstable that use the newly updated glibc 2.3 library. WineX 2.2.1 also includes some substantial performance improvements for many games. The complete list of changes is as follows:

- Support for glibc 2.3, which is now the default glibc version for Debian Unstable
- Improvements in the quality of text rendering in Direct3D mode for WarCraft III and EverQuest
- Direct3D geometry rendering improvements; EverQuest: Shadows of Luclin armour is now visible.
- Performance improvements of 10% in some 3DMark2000 benchmarks
- 200-300% performance improvements in some Quake-3 engine based games such as Jedi Knight 2
- Massive performance improvements for some games such as EverQuest when running on stock RedHat 8.0 kernels
- Support for Quake 3-Engine games based off of Quake 3 1.32